Objective(s): Aberrant expression of CCL5 has been found in several kinds of inflammatory diseases, and the roles of CCL5 in these diseases have also been reported. However, the role of CCL5 in infantile pneumonia is still unclear. Thus, the function and acting mechanism of CCL5 in the in vitro model of infantile pneumonia were researched in this study. Materials and Methods: Human fetal lung f...

The present study was designed to investigate the function of death-associated protein kinase 1 (DAPK1) in infantile pneumonia and explore potential mechanism actions. Male C57BL/6 mice were injected with 2 mg/kg LPS for model pneumonia. A549 cells treated 100 ng/ml vitro Dapk1 mRNA expressions 6, 12 or 24 h after induction mice. gene increased inflammation through activation p38MAPK-mediated N...

Infantile hypotonia or floppy infant is a diagnostic challenge when it presents with other presenting complaints such as fever, cough or diarrhea. Many times the hypotonia goes unnoticed when other symptom covers the hypotonia and child continues to receive the treatment for other symptoms. We report a rare case from Nepal of infantile Pompe disease who presented with the history of fever and c...

In the rare hereditary bone disorder of osteopetrosis, reduced bone resorption function leads to both the development of densely sclerotic fragile bones and progressive obliteration of the marrow spaces and cranial foramina. Marrow obliteration, typically associated with extramedullary hemopoiesis and hepatosplenomegaly, results in anemia and thrombocytopenia and nerve entrapment accounts for p...

in the rare hereditary bone disorder of osteopetrosis, reduced bone resorption function leads to both the development of densely sclerotic fragile bones and progressive obliteration of the marrow spaces and cranial foramina. marrow obliteration, typically associated with extramedullary hemopoiesis and hepatosplenomegaly, results in anemia and thrombocytopenia and nerve entrapment accounts for p...

There are two clinical types of Pompe disease: infantile-onset and late-onset, while the former is much more severe.We reported a typical case disease in 9-month infant who presenting with repeated pneumonia, growth retardation hypomyotonia, hepatomegaly, accompany elevated serum creatine kinase liver transaminase. Cardiac magnetic resonance (CMR) showed marked hypertrophy both ventricles inclu...

Statistical review The material for review was collected from the records of three Dublin Hospitals for the years 1937 to 1939. All patients dying within twentyfour hours of admission, or in whom signs of improvement had set in before starting treatment, were excluded. The cases were clinically divided into the two groups of lobar and atypical pneumonia. The former showed clinical evidence of l...

In the rare hereditary bone disorder of osteopetrosis, reduced bone resorption function leads to both the development of densely sclerotic fragile bones and progressive obliteration of the marrow spaces and cranial foramina. Marrow obliteration, typically associated with extramedullary hemopoiesis and hepatosplenomegaly, results in anemia and thrombocytopenia; and nerve entrapment accounts for ...

cautiously. Only a few relatives have been examined , and therefore ascertainment of the correct diagnosis by history alone is difficult. Increased heritability in PD is suggested by the occasional occurrence of PD in large kindreds and in monozygotic twins [4]. We and others have provided evidence that a subgroup of PD patients, particularly those with prominent tremor, have a genetic suscepti...